A novelty detection algorithm inspired by human audio pattern recognition is conceptualized and experimentally tested. This anomaly detection technique can be used to monitor the health of a machine or could also be coupled with a current state of the art system to enhance its fault detection capabilities. Time-domain data obtained from a microphone is processed by applying a short-time FFT, which returns time-frequency patterns. Such patterns are fed to a machine learning algorithm, which is designed to detect novel signals and identify windows in the frequency domain where such novelties occur. The algorithm presented in this paper uses one-dimensional kernel density estimation for different frequency bins. This process eliminates the need for data dimension reduction algorithms. The method of “pseudo-likelihood cross validation” is used to find an independent optimal kernel bandwidth for each frequency bin. Metrics such as the “Individual Node Relative Difference” and “Total Novelty Score” are presented in this work, and used to assess the degree of novelty of a new signal. Experimental datasets containing synthetic and real novelties are used to illustrate and test the novelty detection algorithm. Novelties are successfully detected in all experiments. The presented novelty detection technique could greatly enhance the performance of current state-of-the art condition monitoring systems, or could also be used as a stand-alone system.