Ask a Librarian

Threre are lots of ways to contact a librarian. Choose what works best for you.

HOURS TODAY

11:00 am - 3:00 pm

Reference Desk

CONTACT US BY PHONE

(802) 656-2022

Voice

(802) 503-1703

Text

MAKE AN APPOINTMENT OR EMAIL A QUESTION

Schedule an Appointment

Meet with a librarian or subject specialist for in-depth help.

Email a Librarian

Submit a question for reply by e-mail.

WANT TO TALK TO SOMEONE RIGHT AWAY?

Library Hours for Friday, March 29th

All of the hours for today can be found below. We look forward to seeing you in the library.
HOURS TODAY
8:00 am - 6:00 pm
MAIN LIBRARY

SEE ALL LIBRARY HOURS
WITHIN HOWE LIBRARY

MapsM-Th by appointment, email govdocs@uvm.edu

Media Services8:00 am - 4:30 pm

Reference Desk11:00 am - 3:00 pm

OTHER DEPARTMENTS

Special Collections10:00 am - 5:00 pm

Dana Health Sciences Library7:30 am - 6:00 pm

 

CATQuest

Search the UVM Libraries' collections

UVM Theses and Dissertations

Browse by Department
Format:
Print
Author:
Kendall, Heather E.
Dept./Program:
Microbiology and Molecular Genetics
Year:
2005
Degree:
PhD
Abstract:
Survival rates of children treated for cancer have dramatically increased over the last 25 years as a result of the development of risk-directed multi-modality treatment protocols. As a result, there is a rapidly growing population of children and young adult cancer survivors in which the long-term genotoxic effects of chemotherapeutic intervention is unknown. The genotoxic effects of chemotherapy on children with hematological malignancies has been investigated by determining their mutant frequencies (Mfs) and mutational spectra at the hypoxanthine-guanine phosphoribosyl transferase (HPRT) reporter gene locus, in non-malignant peripheral human T-cells. We have previously reported significantly elevated Mfs (30-1300 fold higher) in children following treatment for acute lymphocytic leukemia (ALL). In order to gain insight into the genotoxic effects and the etiology of the observed dramatic increase in Mfs following antineoplastic therapy, we investigated the incidence of microsatellite instability (MSI), reflective of a defect in DNA mismatch repair (MMR), HPRT mutation spectra, as well as the extent of clonal proliferation of HPRT mutant isolates, in children treated for ALL at diagnosis, during chemotherapy, and post-chemotherapy, compared to healthy age-matched controls.